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Aspirin and Macular Degeneration The European Eye study (Journal abstract) found that frequent aspirin use was associated with increased occurrence of age related macular degeneration. The risk of macular degeneration increased with frequency of consumption. For daily aspirin users the risk showed a steady increase with increasing severety of macular degeneration.

Common pain relievers associated with hearing loss. Ibuprofen (Advil) and acetaminophen (Tylenol) use were associated with increased risk of hearing loss, aspirin was not. Increased risk of hearing loss was associated with use of ibuprofen or acetaminophen 2 or more days per week. The study was done with women. (Journal Abstract)

Anti inflammatory drugs and blood pressure medication taken together can cause kidney failure. Several studies point to the combined use of diuretics and non-steroidal anti-inflammatory drugs (NSAIDs) causing kidney injury and failure. NSAIDs are a class of drugs that include aspirin, ibuprofen, Advil, Motrin, Naproxin, Aleve and Celebrex (NSAID list) . Blood pressure medications associated with this problem are diuretics, ACE inhibitors, and angiotensin receptor blockers (ARBs). (Journal abstract) In a French study, acute kidney failure was the most frequently reported adverse drug reaction in patients taking oral antihypertensive drugs.(Journal abstract) One New Zealand study (journal abstract) revealed that of 1210 charts reviewed, 353 were identified as having adverse drug events. Most were low severity with temporary harm. However 4 suffered permanent harm, 9 required intervention to sustain life and in 5 kidney injury contributed to their deaths.